Characterization of adducts formed between human serum albumin and the butadiene metabolite epoxybutanediol

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Characterization of adducts formed between human serum albumin and the butadiene metabolite epoxybutanediol.

1,3-Butadiene (BD) has been classified as a potential human carcinogen. It occurs in the environment as well as in industrial settings. In humans, BD is readily metabolized to reactive epoxides (e.g. 1,2-epoxy-3,4-butanediol). In this study, conjugates between human serum albumin (HSA) and EBD were synthesized (molar ratios of 1:600, 1:1 and 1:0.1; HSA/EBD) under physiological conditions. The 1...

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ژورنال

عنوان ژورنال: Rapid Communications in Mass Spectrometry

سال: 2005

ISSN: 0951-4198,1097-0231

DOI: 10.1002/rcm.2086